Table 1.

Skin manifestations associated with anti TNF-α therapy: lupus and lupus-like syndromes.

Comparison of Antibodies in Anti-Tumor Necrosis Factor-α Induced Lupus Erythematosus as Reported in Three Different Studiesa
Autoantibody Costa et al., 2008, (UK), (n=33) Ramos et al., 2007, (Spain), (n=72) De Bandt et al., 2005, (France), (n=12)
ANA, n (%) 32/32 (100) 57 (79) 12 (100)
dsDNA, n (%) 29/32 52 (72) 11(92)
Histone, n (%) 16/28 (57) Not reported 2 (17)
aPL, n (%) Not reported 8 (11) 6 (50)
ENAs, n (%) 10/19 (53) Anti-Sm 7 (10), Anti-RO/La 9 (12), Anti-RNP 5 (7) 5 (42)

Abbreviations: ANA, antinuclear antibodies; dsDNA, double-stranded DNA; aPL, antiphospholipid antibodies; ENAs, extractable nuclear antigens.

• Infliximab induces ANA and anti-dsDNA in 63% and 13% of pts with RA and in 49% and 21.5% of pts with Crohn disease

• Etanercept induces ANA and anti-dsDNA in 11% and 15% of pts

• Adalimumab induces ANA and anti-dsDNA in 5.3% and 12.9% of pts

2013 April-June; 2(2): 67–71. ISSN: 2282-4103
Published online 2013 October 23.