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Clinical Dermatology

Secondary syphilis with granulomatous histology.
A diagnostic challenge

Case-Based review, 115 - 117
doi: 10.11138/cderm/2017.5.3.115
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Secondary syphilis occurs within weeks to months after primary infection with the spirochete Treponema Pallidum. A diffuse symmetric macular and/or papular eruption involving the trunk and extremities, including the palms and soles is the most characteristic finding. Atypical histology may present a diagnostic challenge.
We report a 27-year-old woman with a one-year history of multiple scaly and erythematous macules and plaques over her torso, arms and legs.
The biopsy showed sarcoid-like granulomatous histology. Further investigations failed to support a diagnosis of sarcoidosis and a subsequent TPHA test was positive confirming the diagnosis. Syphilis should be considered in any case of a diffuse macular or papular eruption, with granulomatous histology.

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  1. Secondary syphilis with granulomatous histology.
    A diagnostic challenge

    Drumm C., Tait C.P.
    doi: 10.11138/cderm/2017.5.3.115