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Clinical Dermatology

Therapeutic approaches in psoriasis: a post-hoc analysis of the PSYCHAE study from a gender point of view

Original Article, 77 - 83
doi: 10.11138/cderm/2014.2.2.077
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Abstract
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PSYCHAE was a multicenter observational study conducted in 2004-2005, which included 1580 psoriatic patients. We performed a post-hoc analysis to explore gender differences and the gender-specific therapeutic approaches adopted by Italian dermatologists. Type, severity and duration of psoriasis, presence of psoriatic arthritis, General Health Questionnaire score, Brief COPE questionnaire, Brief Symptom Inventory indexes and prescribed therapies were compared between genders.
786 patients were evaluable for the analysis, 477 (61%) males. Highly significant differences were found in frequency of alcohol consumption and of smokers, which were higher in men, and in GHQ-12 and all BSI scores, which were all significantly worse in women at baseline. Other significant differences were familiarity for psoriasis or arthritis
(higher in women), and severity of psoriasis (higher in men). Topical pharmacological therapy was the most prescribed treatment in both genders and no significant differences were observed in prescribed therapies, except for phototherapy (37% of males vs 29% of females; p=0.0121).
With the major limitation of referring to a cohort studied in 2004-2005, when biologicals were not used yet for psoriasis, this analysis shows that, at that time, Italian dermatologists seemed to have the same approach in treating male and female patients with psoriasis, although females should have deserved more attention to their higher psychological distress.

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