Cic edizioni internazionali
Clinical Dermatology

Clinical evaluation of AKBBA in the management of psoriasis

Original Article, 17 - 24
doi: 10.11138/cderm/2014.2.1.017
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Abstract
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Introduction. Psoriasis is a common chronic inflammatory, immune-mediated disease that predominantly affects the skin and joints, characterized by circumscribed, red, thickened plaques with an overlying silver-white scale (1). Though many pharmaceutical drugs and biologics are available in the market, they have very less impact on the psoriatic patients due to their own and many limitations.
Therefore, as a complementary and alternative medicine (CAM), Boswellia serrata Roxb has been explored and found to be safe and efficient in the management of mild to moderate psoriasis.
Objective. In the current study, we aimed at investigating a cream of Boswellia serrata Roxb extract
standardized for 5% of 95% 3-O-Acetyl-11-Keto Beta Boswellic Acid (AKBBA) (in the form of a cream), for the management of mild to moderate chronic plaque Psoriasis.
Method. An open label, multi centred phase III clinical trial, evaluating 200 psoriatic patients with application of AKBBA cream thrice a day for a period of 12 weeks was carried out. Changes in ‘modified’ Psoriasis Activity Severity Index (PASI) & biomarkers (LTB4, TNF alpha, VEGF, PGE2) from the baseline values along with remissions in clinical lesions observed through photographic images were considered for efficacy evaluation.
Results. Highly significant changes in LTB4 (p<0.001) & TNF alpha (p<0.01) values from the baseline along with significant changes (p<0.05) in VEGF & PGE2 were observed. Reduction in ‘modified’ PASI score from the baseline visit was in consensus with the global evaluations by physician and patients.
Conclusion. We propose topical application of AKBBA cream, may be useful in the management of mild to moderate chronic plaque psoriasis.

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