Hedgehog pathway inhibitors for basal cell carcinoma: case reports and review of the literature
Case-based review, 47 - 50Tag this article
Sonic Hedgehog inhibitors (SHHis) are a novel treatment for locally advanced and metastatic BCC’s not amenable to, or refractory to surgery or radiotherapy. Use can be limited by significant side effects and recurrence. Two cases of recurrent, infiltrating and metastatic tumours demonstrating excellent responses to SHHis are presented. Case one is a 43-year old man with recurrent, locally advanced, inoperable facial BCC that shows a complete response to vismodegib. Case two is a 58-year old man with metastatic BCC that demonstrates complete resolution of metastatic disease and improvement of local disease with sonidegib. Both cases demonstrate dramatic and sustained clinical responses to SHHis. Such medications provide hope for such advanced tumours.
KEY WORDS: advanced basal cell carcinoma; sonidegib; vismodegib; hedgehog inhibitors.