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Clinical Dermatology

Possible role of mast cells and IL-37 in the pathogenesis of psoriasis

Review, 30 - 36
doi: 10.11138/cderm/2017.5.1.030
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Abstract
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Psoriasis (PsA) is an autoimmune skin disease characterized by an excessive keratinocyte proliferation, abnormal differentiation, angiogenesis, over-expression of several cytokines/chemokines and elevated mast cell (MC) number. MCs in PsA mediate the chronic inflammation of the skin, contributing to the disease pathogenesis. MCs are usually associated to immediate hypersensitivity and allergic disorders and play an important role in innate and acquired immunity. They respond to many different stimuli including cytokines [interleukin (IL)-1 and IL-33], and microbes and their products (LPS) which bind TLR-4, leading to and causing the generation of MC pro-inflammatory cytokines.
In the inflammatory site, keratinocytes and MCs cross-talk and cooperate, amplifying inflammatory disorders including PsA. In fact, macrophages generate IL-1 and IL-33 which induce NF-kB and MAPK and activate MCs to release TNF, IL-6 and other pro-inflammatory cytokines/chemokines. In this paper, we report an important inhibitory effect of IL-37 on MC pro-inflammatory cytokine generation.
IL-37 strongly suppresses pro-inflammatory cytokines, including IL-33 and TNF, in MCs activated by IL-1 in psoriatic plaques. This effect describes the importance of IL-37 in the pathogenesis of PsA, mediated by MCs and highlights new therapeutic strategies.

Vol. 5 (No. 1) 2017 January - March

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  1. Possible role of mast cells and IL-37 in the pathogenesis of psoriasis
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    doi: 10.11138/cderm/2017.5.1.030
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